Understanding Weight Loss Medications: Semaglutide and Tirzepatide
Weight loss medications like semaglutide and tirzepatide have transformed the way people approach weight management. Originally developed to manage type 2 diabetes, these medications help regulate blood sugar levels and have also been found to support weight loss. But how do they work?

Semaglutide and tirzepatide belong to a class of medications known as GLP-1 receptor agonists. These drugs mimic a hormone called glucagon-like peptide-1 (GLP-1), which plays a key role in appetite regulation and digestion. By slowing stomach emptying and interacting with hunger-related pathways in the brain, they can help reduce cravings and promote a feeling of fullness—ultimately supporting gradual, sustainable weight loss when combined with a healthy lifestyle.

Multiple clinical trials have shown that these medications may significantly reduce body weight over time. While effective, they are typically prescribed as part of a broader medical plan and are not intended to replace lifestyle changes such as balanced eating and regular physical activity.

Who Might Benefit from GLP-1 Medications?
These medications are generally considered for individuals who:

Have a body mass index (BMI) of 30 or higher, or

Have a BMI of 27 or higher with weight-related health conditions such as type 2 diabetes, high blood pressure, or high cholesterol.

Who Should Avoid GLP-1 Medications?
GLP-1 receptor agonists are not suitable for everyone. They are typically not recommended for individuals with:

A history of pancreatitis

A personal or family history of medullary thyroid carcinoma (MTC)

Multiple endocrine neoplasia syndrome type 2 (MEN2)

Type 1 diabetes

Understanding how these medications work—and knowing who they may or may not be appropriate for—can help individuals have informed discussions with their healthcare provider about potential treatment options.